Pharmacological effects of mulberry extract

Mulberry extract is the ear extract of the mulberry plant in the mulberry family

pharmacological action

Immunomodulatory effect

Research has shown that the material basis for mulberry immune regulation is mulberry polysaccharides. Research has found that mulberry water extract is a new activator of receptor TLP4, which can induce the immune response of Th1 cells and regulate immune function.

In vitro immune regulation studies were conducted on ethanol solution and insoluble substances of mulberry, and it was found that ethanol solution of mulberry has a good ability to inhibit abdominal inflammation, regulate spleen cell activation, and make immune cells tend to Th2 immune response.

Mulberry ethanol insoluble substances have significant anti-inflammatory effects in vitro experiments, with their main components being polysaccharides and proteins. Therefore, this may be a potential immunoactive component in Mulberry. Further research has found that mulberry polysaccharides have the potential to regulate Th1 immune tendency and have an impact on changes in splenic lymphocyte composition.

Protecting neural cells

Mulberry anthocyanins and oxidized resveratrol both have good protective effects on the nervous system and are expected to become basic drugs for the treatment of Parkinson's syndrome.

Recently, it has been found that mulberry can protect dopaminergic neurons in Parkinson's disease models caused by toxins, which may be helpful in preventing and treating Parkinson's syndrome.

The experiment confirmed that the oxidized resveratrol in mulberry can inhibit the neurotoxicity of Parkinson's disease models. The protective effect of mulberry extract on PC12 cells in hydrogen peroxide environment was studied, and it was found that the extract has a protective effect on simulated ischemia and glucose deficient PC12 cells. At the same time, experiments using a mouse brain ischemia model confirmed that the cyanidin-3-O-glucoside in mulberry anthocyanins can provide protection for nerve cells during cerebral ischemia.

Antioxidant effect

Mulberries have strong antioxidant effects, and their antioxidant ability is closely related to the content of anthocyanins and other substances.

Research has shown that mulberry, rich in anthocyanins, can enhance the antioxidant and cognitive abilities of premature aging mice, helping to prevent Alzheimer's disease. A study was conducted on the antioxidant capacity of mulberry pigment in vitro. In vitro experiments showed that the extract of mulberry pigment had a certain inhibitory effect on lipid peroxidation, and had varying degrees of scavenging effects on · OH, DPPH ·, and ABTS+, demonstrating strong antioxidant capacity.

Further elucidating the correlation between the scavenging ability of mulberry hydrogen peroxide free radicals and the content of total phenols, anthocyanins, and procyanidins.

Protecting the cardiovascular and cerebrovascular systems

Atherosclerosis is one of the main causes of cardiovascular and cerebrovascular diseases. Studies have found that mulberry anthocyanins can inhibit the oxidation of low-density lipoprotein, and oxidized low-density lipoprotein will induce macrophages to form foam cells, leading to atherosclerosis, suggesting that mulberry extract can effectively prevent atherosclerosis and protect the cardiovascular and cerebrovascular systems.

Anticancer effect

Mulberry anthocyanins can effectively slow down the metastasis and invasion of cancer cells, making them a potential anticancer drug.

A study was conducted on the anti metastasis effect of mulberry anthocyanins on cancer cells, and it was found that mulberry anthocyanins can effectively inhibit the metastasis of melanoma. This effect is related to the Ras/PI3K signaling pathway, and it is suggested that mulberry may become a medium for cancer cell metastasis inhibition.

Research has found that mulberry anthocyanins can effectively inhibit the metastasis and invasion of human lung cancer cell lines.