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Biological origin
The extract powder of Atractylodes macrocephala is mainly from the rhizome of Atractylodes macrocephala, a plant of Compositae.
Chemical composition
Volatile oil: the main components in the oil are Atractylon, Atractylol, Butenolide A, Butenolide B, 3- β- Acetoxyatractylon, 3- β- Hydroxyattractylon, Selena-4 (14), 7 (11) dien-8-one, sesquiterpene (C15H22O). There are various acylation products of atractylol (Tetradeca-2, 8, 10-trien-4, 6-diene-1, 12, 14-triol)
Pharmacological action
1. Diuretic effect
Atractylodes macrocephala decoction and fluid extract have diuretic effect on rats, rabbits, dogs, etc. by gavage or intravenous injection. Atractylodes macrocephala decoction was 0.05~0.25g/kg. After 0.5~1h of intravenous injection to dogs, it began to diuresis. It reached a peak in 2 hours and lasted for 1.5 hours. The average urine volume increased by 9.2 times. After 1~3g/kg of oral administration, the urine volume increased by 2~6 times. Most of them were still more than normal after 6~7h of administration. Atractylodes macrocephala not only increased the excretion of water, but also promoted the excretion of electrolytes, especially sodium. The output of sodium increased by 35.2 times, and the output of chlorine, urine CO2 capacity, pH value and potassium increased in varying degrees.
2. Hypoglycemic effect
The blood sugar of rabbits was slightly reduced after oral administration of the extract powder of Atractylodes macrocephala, while that of rats after oral administration of the decoction could accelerate the assimilation of glucose in the body and thus reduce blood sugar.
3. Anti coagulation
Rats were fed 0.5g/kg decoction every day for 1 to 4 weeks, and the thrombin time was significantly prolonged, and the root was stronger than the stem. Healthy people took 1 tablespoon of root decoction (1:20) three times a day, and the thrombin time and coagulation time were significantly prolonged after 4 days. The thrombin time and coagulation time returned to normal more than 10 days after the drug was stopped. The ethanol extract was also effective, but the maintenance time was short.
4. Immune enhancement
Baizhu decoction can significantly improve the phagocytic function of peritoneal macrophages in mice, making cells larger, phagocytosis increased and nucleus smaller. Studies have shown that Atractylodes macrocephala can significantly increase the number of TH cells in mice with low immune function, increase the THChemicalbook/TS ratio, correct the disorder of TC cell subpopulation distribution, significantly increase the low level of IL-2, and increase the expression of IL-2R on the surface of T lymphocytes, which may be an important mechanism of immune enhancement and immune regulation of Atractylodes macrocephala.
5. Antioxidant effect
Animal experiments show that Atractylodes macrocephala has obvious antioxidant effect, can effectively reduce lipid peroxidation, reduce the content of LPO, can avoid the damage of harmful substances to the structure and function of tissues and cells, and also has the tendency to increase SOD activity, enhance the body's ability to remove free radicals, and reduce the damage of free radicals to the body.
6. Antitire effect
Atractylodes macrocephala extract powder and petroleum ether extract have significant inhibitory effects on spontaneous contraction of isolated uterus of non pregnant mice and excitatory contraction of uterus caused by oxytocin and motherwort, and the inhibitory effect increases with the increase of drug concentration, with a dose effect relationship. Atractylodes macrocephala extract powder can completely antagonize oxytocin induced tension contraction of pregnant guinea pig uterus in vivo. The inhibitory effect of water extract on isolated uterus was weak.
7. Other functions
Atractylodes macrocephala extract powder can increase the weight and muscle strength of animals, and has a strong effect; It has the effect of increasing the leukopenia caused by radiotherapy or chemotherapy; It has inhibitory effect on such fungi as meningococcus, anthrax bacillus, diphtheria bacillus, bacillus subtilis and epidermophyte floccosus; It can inhibit the heart of toad and slow down the heart rate; It can inhibit gastric emptying and promote intestinal transport function in rats; The volatile oil of Atractylodes macrocephala has a sedative effect on Rana temporaria, and a large dose of it has an anesthetic effect; It has significant inhibitory effect on Ehrlich ascites carcinoma.
Specification
SPECIFICATION | ||
Product Name: Atractylodes macrocephala extract powder | Origin of Material: china | |
Botanical Source: Atractylodes macrocephala | Part Used: root | |
ANALYSIS | SPECIFICATION | REMARK |
Appearance | Brown powder | |
Odor | Characteristic | Organoleptic |
Taste | Characteristic | Organoleptic |
Sieve Analysis | 95% pass 80 mesh | |
Loss on Drying | ≤5% | 2 hours at 105°C |
Bulk Density | 40-60g/100ml | |
Total Ash | ≤5% | |
Heavy Metals | ≤10ppm | EP2.4.8 |
As | ≤1ppm | ICP-MS |
Pb | ≤3ppm | ICP-MS |
Microbiological Test | ||
Total Plate Count | ≤10000cfu/g | |
Yeast & Mold | ≤1000cfu/g | |
E.Coli E | Negative | |
Salmonella | Negative | |
Storage: In a cool & dry place. Keep away from strong light and heat. | ||
Shelf Life: 2 years when properly stored. | ||
* There is likely to be minor color variation from batch to batch due to geographical(origin) and seasonal variations of the material. | ||
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Biological origin
The extract powder of Atractylodes macrocephala is mainly from the rhizome of Atractylodes macrocephala, a plant of Compositae.
Chemical composition
Volatile oil: the main components in the oil are Atractylon, Atractylol, Butenolide A, Butenolide B, 3- β- Acetoxyatractylon, 3- β- Hydroxyattractylon, Selena-4 (14), 7 (11) dien-8-one, sesquiterpene (C15H22O). There are various acylation products of atractylol (Tetradeca-2, 8, 10-trien-4, 6-diene-1, 12, 14-triol)
Pharmacological action
1. Diuretic effect
Atractylodes macrocephala decoction and fluid extract have diuretic effect on rats, rabbits, dogs, etc. by gavage or intravenous injection. Atractylodes macrocephala decoction was 0.05~0.25g/kg. After 0.5~1h of intravenous injection to dogs, it began to diuresis. It reached a peak in 2 hours and lasted for 1.5 hours. The average urine volume increased by 9.2 times. After 1~3g/kg of oral administration, the urine volume increased by 2~6 times. Most of them were still more than normal after 6~7h of administration. Atractylodes macrocephala not only increased the excretion of water, but also promoted the excretion of electrolytes, especially sodium. The output of sodium increased by 35.2 times, and the output of chlorine, urine CO2 capacity, pH value and potassium increased in varying degrees.
2. Hypoglycemic effect
The blood sugar of rabbits was slightly reduced after oral administration of the extract powder of Atractylodes macrocephala, while that of rats after oral administration of the decoction could accelerate the assimilation of glucose in the body and thus reduce blood sugar.
3. Anti coagulation
Rats were fed 0.5g/kg decoction every day for 1 to 4 weeks, and the thrombin time was significantly prolonged, and the root was stronger than the stem. Healthy people took 1 tablespoon of root decoction (1:20) three times a day, and the thrombin time and coagulation time were significantly prolonged after 4 days. The thrombin time and coagulation time returned to normal more than 10 days after the drug was stopped. The ethanol extract was also effective, but the maintenance time was short.
4. Immune enhancement
Baizhu decoction can significantly improve the phagocytic function of peritoneal macrophages in mice, making cells larger, phagocytosis increased and nucleus smaller. Studies have shown that Atractylodes macrocephala can significantly increase the number of TH cells in mice with low immune function, increase the THChemicalbook/TS ratio, correct the disorder of TC cell subpopulation distribution, significantly increase the low level of IL-2, and increase the expression of IL-2R on the surface of T lymphocytes, which may be an important mechanism of immune enhancement and immune regulation of Atractylodes macrocephala.
5. Antioxidant effect
Animal experiments show that Atractylodes macrocephala has obvious antioxidant effect, can effectively reduce lipid peroxidation, reduce the content of LPO, can avoid the damage of harmful substances to the structure and function of tissues and cells, and also has the tendency to increase SOD activity, enhance the body's ability to remove free radicals, and reduce the damage of free radicals to the body.
6. Antitire effect
Atractylodes macrocephala extract powder and petroleum ether extract have significant inhibitory effects on spontaneous contraction of isolated uterus of non pregnant mice and excitatory contraction of uterus caused by oxytocin and motherwort, and the inhibitory effect increases with the increase of drug concentration, with a dose effect relationship. Atractylodes macrocephala extract powder can completely antagonize oxytocin induced tension contraction of pregnant guinea pig uterus in vivo. The inhibitory effect of water extract on isolated uterus was weak.
7. Other functions
Atractylodes macrocephala extract powder can increase the weight and muscle strength of animals, and has a strong effect; It has the effect of increasing the leukopenia caused by radiotherapy or chemotherapy; It has inhibitory effect on such fungi as meningococcus, anthrax bacillus, diphtheria bacillus, bacillus subtilis and epidermophyte floccosus; It can inhibit the heart of toad and slow down the heart rate; It can inhibit gastric emptying and promote intestinal transport function in rats; The volatile oil of Atractylodes macrocephala has a sedative effect on Rana temporaria, and a large dose of it has an anesthetic effect; It has significant inhibitory effect on Ehrlich ascites carcinoma.
Specification
SPECIFICATION | ||
Product Name: Atractylodes macrocephala extract powder | Origin of Material: china | |
Botanical Source: Atractylodes macrocephala | Part Used: root | |
ANALYSIS | SPECIFICATION | REMARK |
Appearance | Brown powder | |
Odor | Characteristic | Organoleptic |
Taste | Characteristic | Organoleptic |
Sieve Analysis | 95% pass 80 mesh | |
Loss on Drying | ≤5% | 2 hours at 105°C |
Bulk Density | 40-60g/100ml | |
Total Ash | ≤5% | |
Heavy Metals | ≤10ppm | EP2.4.8 |
As | ≤1ppm | ICP-MS |
Pb | ≤3ppm | ICP-MS |
Microbiological Test | ||
Total Plate Count | ≤10000cfu/g | |
Yeast & Mold | ≤1000cfu/g | |
E.Coli E | Negative | |
Salmonella | Negative | |
Storage: In a cool & dry place. Keep away from strong light and heat. | ||
Shelf Life: 2 years when properly stored. | ||
* There is likely to be minor color variation from batch to batch due to geographical(origin) and seasonal variations of the material. | ||
Certificate
company display
